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Characterization of germline antibody libraries from human umbilical cord blood and selection of monoclonal antibodies to viral envelope glycoproteins: Implications for mechanisms of immune evasion and design of vaccine immunogens

We have previously observed that all known HIV-1 broadly neutralizing antibodies (bnAbs) are highly divergent from germline antibodies in contrast to bnAbs against Hendra virus, Nipah virus and SARS coronavirus (SARS CoV). We have hypothesized that because the germline antibodies are so different fr...

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書誌詳細
主要な著者: Chen, Weizao, Streaker, Emily D., Russ, Daniel E., Feng, Yang, Prabakaran, Ponraj, Dimitrov, Dimiter S.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268823/
https://ncbi.nlm.nih.gov/pubmed/22226962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.12.089
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