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Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation
Hematopoietic stem cells (HSCs) have a unique capacity to undergo self-renewal and multi-lineage differentiation to provide a lifetime supply of mature blood cells. By using conditional knockout technology, we disrupted the c-myb proto-oncogene specifically in adult bone marrow (BM) to demonstrate t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787467/ https://ncbi.nlm.nih.gov/pubmed/19955420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907623106 |
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