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Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: Enhanced cognitive adaptability?

Local availability of glycine near N-methyl-d-aspartate receptors (NMDARs) is partly regulated by neuronal glycine transporter 1 (GlyT1), which can therefore modulate NMDAR function because binding to the glycine site of the NMDAR is necessary for channel activation. Disrupting GlyT1 in forebrain ne...

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Détails bibliographiques
Auteurs principaux: Singer, Philipp, Boison, Detlev, Möhler, Hanns, Feldon, Joram, Yee, Benjamin K.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787403/
https://ncbi.nlm.nih.gov/pubmed/19824767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1037/a0016676
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