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Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: Evidence for age-dependent phenotypes in Pavlovian learning

Genetic deletion of glycine transporter 1 (GlyT1) in forebrain neurons gives rise to multiple pro-cognitive phenotypes, presumably due to enhanced N-methyl-d-aspartate receptor (NMDAR) functions. However, concerns over possible harmful excitotoxic effects under life-long elevation of synaptic glycin...

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Detalhes bibliográficos
Main Authors: Dubroqua, Sylvain, Singer, Philipp, Boison, Detlev, Feldon, Joram, Möhler, Hanns, Yee, Benjamin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000315/
https://ncbi.nlm.nih.gov/pubmed/21038935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1037/a0021556
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