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Constitutive activation of tethered-peptide/ corticotropin-releasing factor receptor chimeras

Constitutive activity, or ligand-independent activity, of mutant G protein-coupled receptors (GPCRs) has been described extensively and implicated in the pathology of many diseases. Using the corticotropin-releasing factor (CRF) receptor and the thrombin receptor as a model, we present a ligand-depe...

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Bibliografski detalji
Glavni autori: Nielsen, Søren Møller, Nielsen, Lisa Z., Hjorth, Siv A., Perrin, Marilyn H., Vale, Wylie W.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC27874/
https://ncbi.nlm.nih.gov/pubmed/10963687
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