Regulated Endoplasmic Reticulum-associated Degradation of a Polytopic Protein: p97 RECRUITS PROTEASOMES TO Insig-1 BEFORE EXTRACTION FROM MEMBRANES

Polytopic membrane proteins subjected to endoplasmic reticulum (ER)-associated degradation are extracted from membranes and targeted to proteasomes for destruction. The extraction mechanism is poorly understood. One polytopic ER protein subjected to ER-associated degradation is Insig-1, a negative r...

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Detalhes bibliográficos
Main Authors: Ikeda, Yukio, DeMartino, George N., Brown, Michael S., Lee, Joon No, Goldstein, Joseph L., Ye, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787351/
https://ncbi.nlm.nih.gov/pubmed/19815544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.044875
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