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Unsaturated Fatty Acids Inhibit Proteasomal Degradation of Insig-1 at a Postubiquitination Step

Proteasomes mediate the regulated degradation of Insig-1, a membrane protein of the endoplasmic reticulum (ER) that plays a crucial role in lipid metabolism. We showed previously that sterols inhibit this degradation by blocking ubiquitination of Insig-1. Here we show that unsaturated fatty acids st...

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Bibliografiske detaljer
Main Authors: Lee, Joon No, Zhang, Xiangyu, Feramisco, Jamison D., Gong, Yi, Ye, Jin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586246/
https://ncbi.nlm.nih.gov/pubmed/18835813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806108200
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