Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

Upon activation by therapeutics, the nuclear xenobiotic/ constitutive active/androstane receptor (CAR) regulates various liver functions ranging from drug metabolism and excretion to energy metabolism. CAR can also be a risk factor for developing liver diseases such as hepatocellular carcinoma. Here...

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Hlavní autoři: Mutoh, Shingo, Osabe, Makoto, Inoue, Kaoru, Moore, Rick, Pedersen, Lee, Perera, Lalith, Rebolloso, Yvette, Sueyoshi, Tatsuya, Negishi, Masahiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787341/
https://ncbi.nlm.nih.gov/pubmed/19858220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048108
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