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Advances in Tau-focused drug discovery for Alzheimer's disease and related tauopathies

Neuronal inclusions comprised of the microtubule-associated protein tau are found in a number of neurodegenerative diseases, commonly known as tauopathies. In Alzheimer's disease, the most prevalent tauopathy, misfolded tau is probably a key pathological agent. The recent failure of Aβ-targeted...

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Autores principales: Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787232/
https://ncbi.nlm.nih.gov/pubmed/19794442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd2959
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