Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Dying cells are capable of activating the innate immune system and inducing a sterile inflammatory response. Here, we show that necrotic cells are sensed by the Nlrp3 inflammasome resulting in the subsequent release of the proinflammatory cytokine IL-1β. Necrotic cells produced by pressure disruptio...

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Autori principali: Iyer, Shankar S., Pulskens, Wilco P., Sadler, Jeffrey J., Butter, Loes M., Teske, Gwendoline J., Ulland, Tyler K., Eisenbarth, Stephanie C., Florquin, Sandrine, Flavell, Richard A., Leemans, Jaklien C., Sutterwala, Fayyaz S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787135/
https://ncbi.nlm.nih.gov/pubmed/19918053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908698106
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