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Single molecule measurement of the “speed limit” of DNA polymerase

Although DNA replication is often imagined as a regular and continuous process, the DNA polymerase enzyme is a complicated machine and can pause upon encountering physical and chemical barriers. We used single molecule measurements to make a detailed characterization of this behavior as a function o...

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Detalles Bibliográficos
Main Authors: Schwartz, Jerrod J., Quake, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787106/
https://ncbi.nlm.nih.gov/pubmed/19906998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907404106
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