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Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation

The modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the two major DNA epigenetic modifications in mammalian genomes and play crucial roles in development and pathogenesis. Little is known about the colocalization or potential correlation of these two modifications. Here w...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Song, Chun-Xiao, Diao, Jiajie, Brunger, Axel T., Quake, Stephen R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843451/
https://ncbi.nlm.nih.gov/pubmed/27035984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600223113
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