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Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation

The modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the two major DNA epigenetic modifications in mammalian genomes and play crucial roles in development and pathogenesis. Little is known about the colocalization or potential correlation of these two modifications. Here w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Song, Chun-Xiao, Diao, Jiajie, Brunger, Axel T., Quake, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843451/
https://ncbi.nlm.nih.gov/pubmed/27035984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600223113
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