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Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation

The modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the two major DNA epigenetic modifications in mammalian genomes and play crucial roles in development and pathogenesis. Little is known about the colocalization or potential correlation of these two modifications. Here w...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Song, Chun-Xiao, Diao, Jiajie, Brunger, Axel T., Quake, Stephen R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843451/
https://ncbi.nlm.nih.gov/pubmed/27035984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600223113
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