The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA

The DH-PH domain tandems of Dbl-homology guanine nucleotide exchange factors catalyze the exchange of GTP for GDP in Rho-family GTPases, and thus initiate a wide variety of cellular signaling cascades. Although several crystal structures of complexes of DH-PH tandems with cognate, nucleotide free Rh...

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Autores principales: Cierpicki, Tomasz, Bielnicki, Jakub, Zheng, Meiying, Gruszczyk, Jakub, Kasterka, Marta, Petoukhov, Maxim, Zhang, Aming, Fernandez, Erik J, Svergun, Dmitri I, Derewenda, Urszula, Bushweller, John H, Derewenda, Zygmunt S
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786971/
https://ncbi.nlm.nih.gov/pubmed/19670212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.219
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