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Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean

Several human genetic disorders of hemoglobin have risen in frequency because of the protection they offer against death from malaria, sickle-cell anemia being a canonical example. Here we address the issue of why this highly protective mutant, present at high frequencies in subSaharan Africa, is un...

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Detalhes bibliográficos
Main Authors: Penman, Bridget S., Pybus, Oliver G., Weatherall, David J., Gupta, Sunetra
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786893/
https://ncbi.nlm.nih.gov/pubmed/19955437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910840106
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