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Protonation of Individual Histidine Residues Is Not Required for the pH-Dependent Entry of West Nile Virus: Evaluation of the “Histidine Switch” Hypothesis

Histidine residues have been hypothesized to function as sensors of environmental pH that can trigger the activity of viral fusion proteins. We investigated a requirement for histidine residues in the envelope (E) protein of West Nile virus during pH-dependent entry into cells. Each histidine was in...

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Detalhes bibliográficos
Main Authors: Nelson, Steevenson, Poddar, Subhajit, Lin, Tsai-Yu, Pierson, Theodore C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786769/
https://ncbi.nlm.nih.gov/pubmed/19776132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01072-09
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