Persistence of Transgene Expression Influences CD8(+) T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus

Previous studies determined that the CD8(+) T-cell response elicited by recombinant adenovirus exhibited a protracted contraction phase that was associated with long-term presentation of antigen. To gain further insight into this process, a doxycycline-regulated adenovirus was constructed to enable...

Full description

Saved in:
Bibliographic Details
Main Authors: Finn, Jonathan D., Bassett, Jennifer, Millar, James B., Grinshtein, Natalie, Yang, Teng Chih, Parsons, Robin, Evelegh, Carole, Wan, Yonghong, Parks, Robin J., Bramson, Jonathan L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786755/
https://ncbi.nlm.nih.gov/pubmed/19759135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00593-09
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items