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Structure-Function Analysis of Human Immunodeficiency Virus Type 1 gp120 Amino Acid Mutations Associated with Resistance to the CCR5 Coreceptor Antagonist Vicriviroc

Vicriviroc (VCV) is a small-molecule CCR5 coreceptor antagonist currently in clinical trials for treatment of R5-tropic human immunodeficiency virus type 1 (HIV-1) infection. With this drug in development, identification of resistance mechanisms to VCV is needed to allow optimal outcomes in clinical...

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Main Authors: Ogert, Robert A., Ba, Lei, Hou, Yan, Buontempo, Catherine, Qiu, Ping, Duca, Jose, Murgolo, Nicholas, Buontempo, Peter, Ralston, Robert, Howe, John A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786753/
https://ncbi.nlm.nih.gov/pubmed/19776131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01351-09
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