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Human Cytomegalovirus IE1-72 Protein Interacts with p53 and Inhibits p53-Dependent Transactivation by a Mechanism Different from That of IE2-86 Protein

Infection of host cells with human cytomegalovirus (HCMV) induces cell cycle dysregulation. Two HCMV immediate-early (IE) proteins, IE1-72 and IE2-86, are promiscuous transactivators that have been implicated in the dysregulatory events. Cellular p53 protein is accumulated to high levels in HCMV-inf...

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Bibliografische gegevens
Hoofdauteurs: Hwang, Eung-Soo, Zhang, Zhigang, Cai, Haobin, Huang, David Y., Huong, Shu-Mei, Cha, Chang-Yong, Huang, Eng-Shang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786713/
https://ncbi.nlm.nih.gov/pubmed/19776115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00304-09
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