Evidence that the Human Cytomegalovirus IE2-86 Protein Binds mdm2 and Facilitates mdm2 Degradation

Levels of the p53 tumor suppressor protein are increased in human cytomegalovirus (HCMV)-infected cells and may be important for HCMV pathogenesis. In normal cells p53 levels are kept low due to an autoregulatory feedback loop where p53 activates the transcription of mdm2 and mdm2 binds and ubiquiti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Zhigang, Evers, David L., McCarville, Joseph F., Dantonel, Jean-Christophe, Huong, Shu-Mei, Huang, Eng-Shang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440454/
https://ncbi.nlm.nih.gov/pubmed/16571800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.8.3833-3843.2006
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