Antiapoptotic Proteins Bcl-2 and Bcl-X(L) Inhibit Clostridium difficile Toxin A-Induced Cell Death in Human Epithelial Cells

It has been well established that Clostridium difficile toxin A (TcdA) induces cell death in human epithelial cells. However, the mechanism of TcdA-induced cell death remains to be fully characterized. Here, we show that TcdA induces dose-dependent cell death in ovarian carcinoma and colonic carcino...

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Detalhes bibliográficos
Main Authors: Matte, Isabelle, Lane, Denis, Côté, Élodie, Asselin, Ann-Élise, Fortier, Louis-Charles, Asselin, Claude, Piché, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786492/
https://ncbi.nlm.nih.gov/pubmed/19797069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00485-09
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