Metal Deficiency Increases Aberrant Hydrophobicity of Mutant Superoxide Dismutases That Cause Amyotrophic Lateral Sclerosis

The mechanisms by which mutant variants of Cu/Zn-superoxide dismutase (SOD1) cause familial amyotrophic lateral sclerosis are not clearly understood. Evidence to date suggests that altered conformations of amyotrophic lateral sclerosis mutant SOD1s trigger perturbations of cellular homeostasis that...

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Bibliografiset tiedot
Päätekijät: Tiwari, Ashutosh, Liba, Amir, Sohn, Se Hui, Seetharaman, Sai V., Bilsel, Osman, Matthews, C. Robert, Hart, P. John, Valentine, Joan Selverstone, Hayward, Lawrence J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Protein Structure and Folding
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785702/
https://ncbi.nlm.nih.gov/pubmed/19651777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043729
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