Metal Deficiency Increases Aberrant Hydrophobicity of Mutant Superoxide Dismutases That Cause Amyotrophic Lateral Sclerosis

The mechanisms by which mutant variants of Cu/Zn-superoxide dismutase (SOD1) cause familial amyotrophic lateral sclerosis are not clearly understood. Evidence to date suggests that altered conformations of amyotrophic lateral sclerosis mutant SOD1s trigger perturbations of cellular homeostasis that...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Tiwari, Ashutosh, Liba, Amir, Sohn, Se Hui, Seetharaman, Sai V., Bilsel, Osman, Matthews, C. Robert, Hart, P. John, Valentine, Joan Selverstone, Hayward, Lawrence J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2009
Θέματα:
Protein Structure and Folding
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785702/
https://ncbi.nlm.nih.gov/pubmed/19651777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043729
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