Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

The saturated fatty acids acylated on Lipid A of lipopolysaccharide (LPS) or bacterial lipoproteins play critical roles in ligand recognition and receptor activation for Toll-like Receptor 4 (TLR4) and TLR2. The results from our previous studies demonstrated that saturated and polyunsaturated fatty...

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Detalhes bibliográficos
Main Authors: Wong, Scott W., Kwon, Myung-Ja, Choi, Augustine M. K., Kim, Hong-Pyo, Nakahira, Kiichi, Hwang, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785667/
https://ncbi.nlm.nih.gov/pubmed/19648648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.044065
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