Identification of a Novel HtrA1-susceptible Cleavage Site in Human Aggrecan: EVIDENCE FOR THE INVOLVEMENT OF HtrA1 IN AGGRECAN PROTEOLYSIS IN VIVO

Mass spectrometry-based proteomic analyses performed on cartilage tissue extracts identified the serine protease HtrA1/PRSS11 as a major protein component of human articular cartilage, with elevated levels occurring in association with osteoarthritis. Overexpression of a catalytically active form of...

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Bibliographische Detailangaben
Hauptverfasser: Chamberland, Angela, Wang, Eunice, Jones, Aled R., Collins-Racie, Lisa A., LaVallie, Edward R., Huang, Ying, Liu, Lin, Morris, Elisabeth A., Flannery, Carl R., Yang, Zhiyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785663/
https://ncbi.nlm.nih.gov/pubmed/19657146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037051
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