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Cholesterol Regulates Glucose-stimulated Insulin Secretion through Phosphatidylinositol 4,5-Bisphosphate

Membrane cholesterol modulates the ability of glucose to stimulate insulin secretion from pancreatic β-cells. The molecular mechanism by which this occurs is not understood. Here, we show that in cultured β-cells, cholesterol acts through phosphatidylinositol 4,5-bisphosphate (PIP(2)) to regulate ac...

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Detalhes bibliográficos
Main Authors: Hao, Mingming, Bogan, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785582/
https://ncbi.nlm.nih.gov/pubmed/19729450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038034
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