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Regulation of Insulin Secretion by Phosphatidylinositol-4,5-Bisphosphate

The role of PIP(2) in pancreatic beta cell function was examined here using the beta cell line MIN6B1. Blocking PIP(2) with PH-PLC-GFP or PIP5KIγ RNAi did not impact on glucose-stimulated secretion although susceptibility to apoptosis was increased. Over-expression of PIP5KIγ improved cell survival...

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Main Authors: Tomas, Alejandra, Yermen, Barbara, Regazzi, Romano, Pessin, Jeffrey E., Halban, Philippe A.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4088956/
https://ncbi.nlm.nih.gov/pubmed/19845918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2009.00996.x
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