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Regulation of Insulin Secretion by Phosphatidylinositol-4,5-Bisphosphate
The role of PIP(2) in pancreatic beta cell function was examined here using the beta cell line MIN6B1. Blocking PIP(2) with PH-PLC-GFP or PIP5KIγ RNAi did not impact on glucose-stimulated secretion although susceptibility to apoptosis was increased. Over-expression of PIP5KIγ improved cell survival...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4088956/ https://ncbi.nlm.nih.gov/pubmed/19845918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2009.00996.x |
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