Synthesis of Free and Proliferating Cell Nuclear Antigen-bound Polyubiquitin Chains by the RING E3 Ubiquitin Ligase Rad5

In replicating yeast, lysine 63-linked polyubiquitin (polyUb) chains are extended from the ubiquitin moiety of monoubiquitinated proliferating cell nuclear antigen (monoUb-PCNA) by the E2-E3 complex of (Ubc13-Mms2)-Rad5. This promotes error-free bypass of DNA damage lesions. The unusual ability of U...

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Detalhes bibliográficos
Main Authors: Carlile, Candice M., Pickart, Cecile M., Matunis, Michael J., Cohen, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785563/
https://ncbi.nlm.nih.gov/pubmed/19706603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043885
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