Tumor Necrosis Factor-α Induces RelA Degradation via Ubiquitination at Lysine 195 to Prevent Excessive Nuclear Factor-κB Activation

Ubiquitination-mediated degradation of the RelA subunit of nuclear factor-κB (NF-κB) is critical for the termination of NF-κB activation. However, the precise mechanism for the ubiquitination of RelA is still not fully understood. Here we report that tumor necrosis factor-α (TNFα) induces RelA polyu...

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Main Authors: Fan, Yihui, Mao, Renfang, Zhao, Yanling, Yu, Yang, Sun, Wenjing, Song, Ping, Shi, Zhongcheng, Zhang, Dekai, Yvon, Eric, Zhang, Hong, Fu, Songbin, Yang, Jianhua
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785559/
https://ncbi.nlm.nih.gov/pubmed/19706600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.018994
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