טוען...
PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K(+) conductance
Human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediate repolarization of cardiac action potentials. Unintended block of hERG1 channels by some drugs can prolong the QT interval and induce arrhythmia. Recently, hERG1 channel agonists were discovered and, based on their mechanisms of action...
שמור ב:
| Main Authors: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2009
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785294/ https://ncbi.nlm.nih.gov/pubmed/19892732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906597106 |
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