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The Link between Inactivation and High-Affinity Block of hERG1 Channels
Block of human ether-à-go-go–related gene 1 (hERG1) K(+) channels by many drugs delays cardiac repolarization, prolongs QT interval, and is associated with an increased risk of cardiac arrhythmia. Preferential block of hERG1 channels in an inactivated state has been assumed because inactivation defi...
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| Udgivet i: | Mol Pharmacol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4429717/ https://ncbi.nlm.nih.gov/pubmed/25855787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.098111 |
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