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The Link between Inactivation and High-Affinity Block of hERG1 Channels

Block of human ether-à-go-go–related gene 1 (hERG1) K(+) channels by many drugs delays cardiac repolarization, prolongs QT interval, and is associated with an increased risk of cardiac arrhythmia. Preferential block of hERG1 channels in an inactivated state has been assumed because inactivation defi...

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Bibliografske podrobnosti
izdano v:Mol Pharmacol
Main Authors: Wu, Wei, Gardner, Alison, Sanguinetti, Michael C.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429717/
https://ncbi.nlm.nih.gov/pubmed/25855787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.098111
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