Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of HIV-1 infection on vaccination with an Ad5 vaccine. We propose that this was due to activation and expansion of Ad5-specific mucosal-homing memor...

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Detaylı Bibliyografya
Asıl Yazarlar: Benlahrech, Adel, Harris, Julian, Meiser, Andrea, Papagatsias, Timos, Hornig, Julia, Hayes, Peter, Lieber, Andre, Athanasopoulos, Takis, Bachy, Veronique, Csomor, Eszter, Daniels, Rod, Fisher, Kerry, Gotch, Frances, Seymour, Len, Logan, Karen, Barbagallo, Romina, Klavinskis, Linda, Dickson, George, Patterson, Steven
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785271/
https://ncbi.nlm.nih.gov/pubmed/19918060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907898106
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