Effect of Rifampin and Nelfinavir on the Metabolism of Methadone and Buprenorphine in Primary Cultures of Human Hepatocytes

We tested the hypothesis that primary cultures of human hepatocytes could predict potential drug interactions with methadone and buprenorphine. Hepatocytes (five donors) were preincubated with dimethyl sulfoxide (DMSO) (vehicle), rifampin, or nelfinavir before incubation with methadone or buprenorph...

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Bibliographic Details
Main Authors: Moody, David E., Fang, Wenfang B., Lin, Shen-Nan, Weyant, Denise M., Strom, Stephen C., Omiecinski, Curtis J.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784702/
https://ncbi.nlm.nih.gov/pubmed/19773542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.028605
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