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Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities

CD137 (4-1BB) is a member of the TNFR-family with co-stimulatory function, triggering pro-survival signals in activated T-cells. Upregulation of CD137 upon stimulation allows identifying and isolating live, human antigen-specific CD8+ T-cells of all phenotypes and therefore provides a comprehensive...

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Autori principali: Wölfl, Matthias, Kuball, Jürgen, Eyrich, Matthias, Schlegel, Paul G., Greenberg, Philip D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784669/
https://ncbi.nlm.nih.gov/pubmed/18561198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.a.20594
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