Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires

High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual's TCR repertoire and directly queries their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets. In this paper, we present a novel strategy to...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Gielis, Sofie, Moris, Pieter, Bittremieux, Wout, De Neuter, Nicolas, Ogunjimi, Benson, Laukens, Kris, Meysman, Pieter
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896208/
https://ncbi.nlm.nih.gov/pubmed/31849987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02820
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