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Pharmacokinetic role of protein binding of mycophenolic acid and its glucuronide metabolite in renal transplant recipients
Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), is used to prevent graft rejection in renal transplant recipients. MPA is glucuronidated to the metabolite MPAG, which exhibits enterohepatic recirculation (EHC). MPA binds for 97% and MPAG binds for 82% to plasma proteins....
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer US
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784070/ https://ncbi.nlm.nih.gov/pubmed/19904584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-009-9136-6 |
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