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Pharmacokinetic role of protein binding of mycophenolic acid and its glucuronide metabolite in renal transplant recipients

Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), is used to prevent graft rejection in renal transplant recipients. MPA is glucuronidated to the metabolite MPAG, which exhibits enterohepatic recirculation (EHC). MPA binds for 97% and MPAG binds for 82% to plasma proteins....

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Detalhes bibliográficos
Main Authors: de Winter, Brenda C. M., van Gelder, Teun, Sombogaard, Ferdi, Shaw, Leslie M., van Hest, Reinier M., Mathot, Ron A. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784070/
https://ncbi.nlm.nih.gov/pubmed/19904584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-009-9136-6
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