Differential Effects of TR Ligands on Hormone Dissociation Rates: Evidence for Multiple Ligand Entry/Exit Pathways

Some nuclear receptor (NR) ligands promote dissociation of radiolabeled bound hormone from the buried ligand binding cavity (LBC) more rapidly than excess unlabeled hormone itself. This result was interpreted to mean that challenger ligands bind allosteric sites on the LBD to induce hormone dissocia...

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Detalhes bibliográficos
Main Authors: Lima, Suzana T. Cunha, Nguyen, Ngoc-Ha, Togashi, Marie, Apriletti, James W., Nguyen, Phuong, Polikarpov, Igor, Scanlan, Thomas S., Baxter, John D., Webb, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784034/
https://ncbi.nlm.nih.gov/pubmed/19729063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2009.08.003
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