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Two-round COLD-PCR-based Sanger sequencing identifies a novel spectrum of low-level mutations in lung adenocarcinoma
Reliable identification of cancer-related mutations in TP53 is often problematic as these mutations can be randomly distributed throughout numerous codons and their relative abundance in clinical samples can fall below the sensitivity limits of conventional sequencing. To ensure the highest sensitiv...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784016/ https://ncbi.nlm.nih.gov/pubmed/19760750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21112 |
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