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Two-round COLD-PCR-based Sanger sequencing identifies a novel spectrum of low-level mutations in lung adenocarcinoma

Reliable identification of cancer-related mutations in TP53 is often problematic as these mutations can be randomly distributed throughout numerous codons and their relative abundance in clinical samples can fall below the sensitivity limits of conventional sequencing. To ensure the highest sensitiv...

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Detalhes bibliográficos
Main Authors: Li, Jin, Milbury, Coren A., Li, Cheng, Makrigiorgos, G. Mike
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784016/
https://ncbi.nlm.nih.gov/pubmed/19760750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21112
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