N-3 Polyunsaturated Fatty Acids Suppress Insulin-induced SREBP-1c Transcription via Reduced Trans-activating Capacity of LXRα

Insulin coordinately up-regulates lipogenic gene transcription via induction of sterol regulatory element binding protein-1c (SREBP-1c). Conversely, polyunsaturated fatty acids (PUFA) decrease lipogenic gene transcription via suppression of SREBP-1c. We therefore examined the ability of n-3 PUFA to...

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Detalhes bibliográficos
Main Authors: Howell, George, Deng, Xiong, Yellaturu, Chandrahassa, Park, Edwards A., Wilcox, Henry G., Raghow, Rajendra, Elam, Marshall B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783506/
https://ncbi.nlm.nih.gov/pubmed/19716432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2009.08.008
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