Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries

4-vinylcyclohexene diepoxide (VCD) is an ovotoxicant that specifically destroys primordial and small primary follicles in the ovaries of mice and rats. In contrast, 7,12-dimethylbenz[a]anthracene (DMBA) is ovotoxic to all ovarian follicle classes. This study investigated phosphatidylinositol-3 kinas...

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Bibliografiske detaljer
Main Authors: Keating, Aileen F., Mark, Connie J., Sen, Nivedita, Sipes, I. Glenn, Hoyer, Patricia B.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783260/
https://ncbi.nlm.nih.gov/pubmed/19695275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.08.012
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