Dual protective role for Glutathione S-transferase class pi against VCD-induced ovotoxicity in the rat ovary

The occupational chemical 4-vinylcyclohexene diepoxide (VCD) selectively destroys ovarian small pre-antral follicles in rats and mice via apoptosis. Detoxification of VCD can occur through glutathione conjugation, catalyzed by glutathione S-transferase (GST) enzymes. Further, GST class pi (GSTp) can...

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Bibliografische gegevens
Hoofdauteurs: Keating, Aileen F., Sen, Nivedita, Sipes, I. Glenn, Hoyer, Patricia B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925419/
https://ncbi.nlm.nih.gov/pubmed/20542051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.06.002
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