Glutathione S-transferase class mu regulation of apoptosis signal-related kinase 1 protein during VCD-induced ovotoxicity in neonatal rat ovaries

4-vinylcyclohexene diepoxide (VCD) destroys ovarian primordial and small primary follicles via apoptosis. In mice, VCD exposure induces ovarian mRNA expression of glutathione S-transferase (GST) family members, including isoform mu (Gstm). Extra-ovarian GSTM negatively regulates pro-apoptotic apopto...

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Main Authors: Bhattacharya, Poulomi, Madden, Jill A., Sen, Nivedita, Hoyer, Patricia B., Keating, Aileen F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575192/
https://ncbi.nlm.nih.gov/pubmed/23274565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.12.013
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