Evaluation of ovotoxicity induced by 7, 12-dimethylbenz[a]anthracene and its 3,4-diol metabolite utilizing a rat in vitro ovarian culture system

The polycyclic aromatic hydrocarbon 7, 12-dimethylbenz[a]anthracene, (DMBA), targets and destroys all follicle types in rat and mouse ovaries. DMBA requires bioactivation to DMBA-3,4-diol-1,2-epoxide for ovotoxicity via formation of the intermediate, DMBA-3,4-diol (catalyzed by microsomal epoxide hy...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Igawa, Yoshiyuki, Keating, Aileen F., Rajapaksa, Kathila S., Sipes, I. Glenn, Hoyer, Patricia B.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666049/
https://ncbi.nlm.nih.gov/pubmed/19027032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2008.10.009
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker