Evidence for a role of heat shock protein-90 (HSP90) in TLR4 mediated pain enhancement in rats

Spinal cord microglial toll-like receptor-4 (TLR4) has been implicated in enhancing neuropathic pain and opposing morphine analgesia. The present study was initiated to explore TLR4-mediated pain modulation by intrathecal lipopolysaccharide, a classic TLR4 agonist. However, our initial study reveale...

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Detalhes bibliográficos
Main Authors: Hutchinson, Mark R., Ramos, Khara M., Loram, Lisa C., Wieseler, Julie, Sholar, Paige W., Kearney, Jeffrey J., Lewis, Makenzie T., Crysdale, Nicole Y., Zhang, Yingning, Harrison, Jacqueline A., Maier, Steven F., Rice, Kenner C., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783248/
https://ncbi.nlm.nih.gov/pubmed/19788917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2009.09.046
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