Evidence for a role of heat shock protein-90 (HSP90) in TLR4 mediated pain enhancement in rats

Spinal cord microglial toll-like receptor-4 (TLR4) has been implicated in enhancing neuropathic pain and opposing morphine analgesia. The present study was initiated to explore TLR4-mediated pain modulation by intrathecal lipopolysaccharide, a classic TLR4 agonist. However, our initial study reveale...

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Autors principals: Hutchinson, Mark R., Ramos, Khara M., Loram, Lisa C., Wieseler, Julie, Sholar, Paige W., Kearney, Jeffrey J., Lewis, Makenzie T., Crysdale, Nicole Y., Zhang, Yingning, Harrison, Jacqueline A., Maier, Steven F., Rice, Kenner C., Watkins, Linda R.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783248/
https://ncbi.nlm.nih.gov/pubmed/19788917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2009.09.046
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