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Rhodium Catalyzed Enantioselective Cylization of Substituted Imidazoles via C–H Bond Activation

The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98% has been accomplished by rhodium catalyzed C–H bond functionalization with (S,S′,R,R′)TangPhos as the chiral ligand.

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Detalhes bibliográficos
Main Authors: Tsai, Andy S., Wilson, Rebecca M., Harada, Hitoshi, Bergman, Robert G., Ellman, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782779/
https://ncbi.nlm.nih.gov/pubmed/19662249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b902878a
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