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Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer’s mouse model

Mitochondrial dysfunction, oxidative stress and reductions in thiamine-dependent enzymes have been implicated in multiple neurological disorders including Alzheimer's disease (AD). Experimental thiamine deficiency (TD) is an established model for reducing the activities of thiamine-dependent en...

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Detalhes bibliográficos
Main Authors: Karuppagounder, Saravanan S., Xu, Hui, Shi, Qingli, Chen, Lian H., Pedrini, Steve, Pechman, David, Baker, Harriet, Beal, M. Flint, Gandy, Sam E., Gibson, Gary E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782730/
https://ncbi.nlm.nih.gov/pubmed/18406011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.12.013
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