FANCI Protein Binds to DNA and Interacts with FANCD2 to Recognize Branched Structures

In this study, we report that the purified wild-type FANCI (Fanconi anemia complementation group I) protein directly binds to a variety of DNA substrates. The DNA binding domain roughly encompasses residues 200–1000, as suggested by the truncation study. When co-expressed in insect cells, a small fr...

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Detalhes bibliográficos
Main Authors: Yuan, Fenghua, El Hokayem, Jimmy, Zhou, Wen, Zhang, Yanbin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782037/
https://ncbi.nlm.nih.gov/pubmed/19561358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016006
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