Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response

Adaptation to tumor hypoxia is mediated in large part by changes in protein expression. These are driven by multiple pathways, including activation of the hypoxia inducible factor-1 (HIF-1) transcription factor and the PKR-like endoplasmic reticulum kinase PERK, a component of the unfolded protein r...

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Hauptverfasser: van den Beucken, Twan, Koritzinsky, Marianne, Niessen, Hanneke, Dubois, Ludwig, Savelkouls, Kim, Mujcic, Hilda, Jutten, Barry, Kopacek, Juraj, Pastorekova, Sylvia, van der Kogel, Albert J., Lambin, Philippe, Voncken, Willem, Rouschop, Kasper M. A., Wouters, Bradly G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Transcription, Chromatin, and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782014/
https://ncbi.nlm.nih.gov/pubmed/19564335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006510
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